Genetic Disease and Dentistry
Home Modules Mechanisms of Inheritance Clinical Reviews
Resource Links
 
Glossary Index


3) What are Mutations?

Changes in the DNA code (mutations) can be beneficial, neutral, or harmful.
Genetic mutations can be inherited from the mother, from the father, from both, or they can appear for the very first time in an individual (new mutation). Whether a mutation is harmful depends on how the altered code in the DNA affects its instructional message:

Normal message: GET THE RED HAT.
Mutation 1: GET THE RED CAP.

Two letters have changed, but the end product is not significantly altered. This represents a neutral change that is not likely to disrupt the resultant protein and it's function.

Normal message: GET THE RED HAT.
Mutation 2: GET THE RED CAT.

Only one letter has changed, but the end product is significantly altered. This represents a harmful change in the resultant protein product of this gene, which may manifest in disease.



1 OF 3 | NEXT >>